Increased thrombin-activatable fibrinolysis inhibitor levels in patients with chronic rhinosinusitis with nasal polyps.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) is a heterogeneous chronic inflammatory disease subdivided based on the presence or absence of nasal polyps (NPs). Histologic features of chronic rhinosinusitis with nasal polyps (CRSwNP) include inflammatory cell infiltration and excessive fibrin deposition in NPs. Thrombin-activatable fibrinolysis inhibitor (TAFI) is an enzyme that plays an antifibrinolytic role in the body. The significance of TAFI has been documented in patients with chronic inflammatory diseases, including chronic lung disease; however, it has not been evaluated in the pathogenesis of NPs.

Objective

The objective of this study was to evaluate the potential role of TAFI in the pathogenesis of NPs.

Methods

Nasal lavage fluid was collected from control subject

SUBMITTER: Imoto Y 

PROVIDER: S-EPMC6900453 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature