Common variable immunodeficiency-associated endotoxemia promotes early commitment to the T follicular lineage.

ABSTRACT:

Background

Although chiefly a B-lymphocyte disorder, several research groups have identified common variable immunodeficiency (CVID) subjects with numeric and/or functional T_H cell alterations. The causes, interrelationships, and consequences of CVID-associated CD4⁺ T-cell derangements to hypogammaglobulinemia, autoantibody production, or both remain unclear.

Objective

We sought to determine how circulating CD4⁺ T cells are altered in CVID subjects with autoimmune cytopenias (AICs; CVID+AIC) and the causes of these derangements.

Methods

Using hypothesis-generating, high-dimensional single-cell analyses, we created comprehensive phenotypic maps of circulating CD4⁺ T cells. Differences between subject groups were confirmed in

SUBMITTER: Le Coz C 

PROVIDER: S-EPMC6900457 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature