Differentiation of leukemic blasts is not completely blocked in acute myeloid leukemia.

ABSTRACT: Hematopoiesis, the formation of blood cells, involves the hierarchical differentiation of immature blast cells into mature, functional cell types and lineages of the immune system. Hematopoietic stem cells precisely regulate self-renewal versus differentiation to balance the production of blood cells and maintenance of the stem cell pool. The canonical view of acute myeloid leukemia (AML) is that it results from a combination of molecular events in a hematopoietic stem cell that block differentiation and drive proliferation. These events result in the accumulation of primitive hematopoietic blast cells in the blood and bone marrow. We used mathematical modeling to determine the impact of varying differentiation rates on myeloblastic accumulation. Our model shows that, instead of the common

SUBMITTER: Agarwal A 

PROVIDER: S-EPMC6900505 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature