HERES, a lncRNA that regulates canonical and noncanonical Wnt signaling pathways via interaction with EZH2.

ABSTRACT: Wnt signaling through both canonical and noncanonical pathways plays a core role in development. Dysregulation of these pathways often causes cancer development and progression. Although the pathways independently contribute to the core processes, a regulatory molecule that commonly activates both of them has not yet been reported. Here, we describe a long noncoding RNA (lncRNA), HERES, that epigenetically regulates both canonical and noncanonical Wnt signaling pathways in esophageal squamous cell carcinoma (ESCC). For this study, we performed RNA-seq analysis on Korean ESCC patients and validated these results on a larger ESCC cohort to identify lncRNAs commonly dysregulated in ESCCs. Six of the dysregulated lncRNAs were significantly associated with the clinical outcomes of ESCC patients

SUBMITTER: You BH 

PROVIDER: S-EPMC6900598 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature