Clustering and dynamics of crowded proteins near membranes and their influence on membrane bending.

ABSTRACT: Atomistic molecular dynamics simulations of concentrated protein solutions in the presence of a phospholipid bilayer are presented to gain insights into the dynamics and interactions at the cytosol-membrane interface. The main finding is that proteins that are not known to specifically interact with membranes are preferentially excluded from the membrane, leaving a depletion zone near the membrane surface. As a consequence, effective protein concentrations increase, leading to increased protein contacts and clustering, whereas protein diffusion becomes faster near the membrane for proteins that do occasionally enter the depletion zone. Since protein-membrane contacts are infrequent and short-lived in this study, the structure of the lipid bilayer remains largely unaffected by the crowded p

SUBMITTER: Nawrocki G 

PROVIDER: S-EPMC6900600 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature