Protein-assisted RNA fragment docking (RnaX) for modeling RNA-protein interactions using ModelX.

ABSTRACT: RNA-protein interactions are crucial for such key biological processes as regulation of transcription, splicing, translation, and gene silencing, among many others. Knowing where an RNA molecule interacts with a target protein and/or engineering an RNA molecule to specifically bind to a protein could allow for rational interference with these cellular processes and the design of novel therapies. Here we present a robust RNA-protein fragment pair-based method, termed RnaX, to predict RNA-binding sites. This methodology, which is integrated into the ModelX tool suite (http://modelx.crg.es), takes advantage of the structural information present in all released RNA-protein complexes. This information is used to create an exhaustive database for docking and a statistical forcefield for fast dis

SUBMITTER: Delgado Blanco J 

PROVIDER: S-EPMC6900601 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature