A novel network control model for identifying personalized driver genes in cancer.

ABSTRACT: Although existing computational models have identified many common driver genes, it remains challenging to identify the personalized driver genes by using samples of an individual patient. Recently, the methods of exploiting the structure-based control principles of complex networks provide new clues for identifying minimum number of driver nodes to drive the state transition of large-scale complex networks from an initial state to the desired state. However, the structure-based network control methods cannot be directly applied to identify the personalized driver genes due to the unknown network dynamics of the personalized system. Here we proposed the personalized network control model (PNC) to identify the personalized driver genes by employing the structure-based network control princi

SUBMITTER: Guo WF 

PROVIDER: S-EPMC6901264 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature