Desumoylation of RNA polymerase III lies at the core of the Sumo stress response in yeast.

ABSTRACT: Post-translational modification by small ubiquitin-like modifier (Sumo) regulates many cellular processes, including the adaptive response to various types of stress, referred to as the Sumo stress response (SSR). However, it remains unclear whether the SSR involves a common set of core proteins regardless of the type of stress or whether each particular type of stress induces a stress-specific SSR that targets a unique, largely nonoverlapping set of Sumo substrates. In this study, we used MS and a Gene Ontology approach to identify differentially sumoylated proteins during heat stress, hyperosmotic stress, oxidative stress, nitrogen starvation, and DNA alkylation in Saccharomyces cerevisiae cells. Our results indicate that each stress triggers a specific SSR signature centered on p

SUBMITTER: Nguea P A 

PROVIDER: S-EPMC6901327 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature