Regulator of G-protein signaling (RGS) proteins as drug targets: Progress and future potentials.

ABSTRACT: G protein-coupled receptors (GPCRs) play critical roles in regulating processes such as cellular homeostasis, responses to stimuli, and cell signaling. Accordingly, GPCRs have long served as extraordinarily successful drug targets. It is therefore not surprising that the discovery in the mid-1990s of a family of proteins that regulate processes downstream of GPCRs generated great excitement in the field. This finding enhanced the understanding of these critical signaling pathways and provided potentially new targets for pharmacological intervention. These regulators of G-protein signaling (RGS) proteins were viewed by many as nodes downstream of GPCRs that could be targeted with small molecules to tune signaling processes. In this review, we provide a brief overview of the discovery of RGS

SUBMITTER: O'Brien JB 

PROVIDER: S-EPMC6901330 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature