Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection.

ABSTRACT: Sustained viremia after acute HIV infection is associated with profound CD4⁺ T cell loss and exhaustion of HIV-specific CD8⁺ T cell responses. To determine the impact of combination antiretroviral therapy (cART) on these processes, we examined the evolution of immune responses in acutely infected individuals initiating treatment before peak viremia. Immediate treatment of Fiebig stages I and II infection led to a rapid decline in viral load and diminished magnitude of HIV-specific (tetramer⁺) CD8⁺ T cell responses compared to untreated donors. There was a strong positive correlation between cumulative viral antigen exposure before full cART-induced suppression and immune responses measured by MHC class I tetramers, IFN-γ ELISPOT, and CD8⁺

SUBMITTER: Ndhlovu ZM 

PROVIDER: S-EPMC6901350 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature