Neural and neurocognitive markers of vulnerability to gambling disorder: a study of unaffected siblings.

ABSTRACT: Psychological and neurobiological markers in individuals with gambling disorder (GD) could reflect transdiagnostic vulnerability to addiction or neuroadaptive consequences of long-term gambling. Using an endophenotypic approach to identify vulnerability markers, we tested the biological relatives of cases with GD. Male participants seeking treatment for GD (n = 20) were compared with a male control group (n = 18). Biological siblings of cases with GD (n = 17, unrelated to the current GD group) were compared with a separate control group (n = 19) that overlapped partially with the GD control group. Participants completed a comprehensive assessment of clinical scales, neurocognitive functioning, and fMRI of unexpected financial reward. The GD group displayed elevated levels of self-report im

SUBMITTER: Limbrick-Oldfield EH 

PROVIDER: S-EPMC6901470 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature