Genome investigations show host adaptation and transmission of LA-MRSA CC398 from pigs into Danish healthcare institutions.

ABSTRACT: Over the last decade, an increasing number of infections with livestock-associated methicillin-resistant Staphylococcus aureus of clonal complex 398 (LA-MRSA CC398) in persons without contact to livestock has been registered in Denmark. These infections have been suggested to be the result of repeated spillover of random isolates from livestock into the community. However, other studies also found emerging sub-lineages spreading among humans. Based on genome-wide SNPs and genome-wide association studies (GWAS), we assessed the population structure and genomic content of Danish LA-MRSA CC398 isolates from healthcare-associated infections from 2014 to 2016 (n = 73) and compared these to isolates from pigs in Denmark from 2014 (n = 183). Phylogenetic analyses showed that most human isolates w

SUBMITTER: Sieber RN 

PROVIDER: S-EPMC6901509 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature