Aging mice show impaired memory updating in the novel OUL updating paradigm.

ABSTRACT: Memories do not persist in a permanent, static state but instead must be dynamically modified in response to new information. Although new memory formation is typically studied in a laboratory setting, most real-world associations are modifications to existing memories, particularly in the aging, experienced brain. To date, the field has lacked a simple behavioral paradigm that can measure whether original and updated information is remembered in a single test session. To address this gap, we have developed a novel memory updating paradigm, called the Objects in Updated Locations (OUL) task that is capable of assessing memory updating in a non-stressful task that is appropriate for both young and old rodents. We first show that young mice successfully remember both the original memory and

SUBMITTER: Kwapis JL 

PROVIDER: S-EPMC6901557 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature