Association of Anticoagulant Therapy With Risk of Fracture Among Patients With Atrial Fibrillation.

ABSTRACT:

Importance

Warfarin is prescribed to patients with atrial fibrillation (AF) for the prevention of cardioembolic complications. Whether warfarin adversely affects bone health is controversial. The availability of alternate direct oral anticoagulant (DOAC) options now make it possible to evaluate the comparative safety of warfarin in association with fracture risk.

Objective

To test the hypothesis that, among patients with nonvalvular AF, use of DOACs vs warfarin is associated with lower risk of incident fracture.

Design, setting, and participants

This comparative effectiveness cohort study used the MarketScan administrative claims databases to identify patients with nonvalvular AF and who were prescribed oral anticoagulants from January 1, 2010, through September 30, 2

SUBMITTER: Lutsey PL 

PROVIDER: S-EPMC6902159 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature