Association Between Obesity-Mediated Atrial Fibrillation and Therapy With Sodium Channel Blocker Antiarrhythmic Drugs.

ABSTRACT:

Importance

The association between obesity, an established risk factor for atrial fibrillation (AF), and response to antiarrhythmic drugs (AADs) remains unclear.

Objective

To test the hypothesis that obesity differentially mediates response to AADs in patients with symptomatic AF and in mice with diet-induced obesity (DIO) and pacing induced AF.

Design, setting, and participants

An observational cohort study was conducted including 311 patients enrolled in a clinical-genetic registry. Mice fed a high-fat diet for 10 weeks were also evaluated. The study was conducted from January 1, 2018, to June 2, 2019.

Main outcomes and measures

Symptomatic response was defined as continuation of the same AAD for at least 3 months. Nonresponse was defined as discontinuation o

SUBMITTER: Ornelas-Loredo A 

PROVIDER: S-EPMC6902234 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature