Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study.

ABSTRACT:

Background

Enrichment strategies improve therapeutic targeting and trial efficiency, but enrichment factors for sepsis trials are lacking. We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and angiopoietin-2 (Ang2) could identify sepsis patients at higher mortality risk and serve as prognostic enrichment factors.

Methods

In a multicenter prospective cohort study of 400 critically ill septic patients, we derived and validated thresholds for each marker and expressed prognostic enrichment using risk differences (RD) of 30-day mortality as predictive values. We then used decision curve analysis to simulate the prognostic enrichment of each marker and compare different prognostic enrichment strategies.

Measurements

SUBMITTER: Anderson BJ 

PROVIDER: S-EPMC6902425 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature