Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer.

ABSTRACT: Hepatocellular carcinoma (HCC, also called primary liver cancer) is one of the most fatal cancers in the world. Due to the insidiousness of the onset of HCC and the lack of effective treatment methods, the prognosis of HCC is extremely poor, and the 5-year average survival rate is less than 10%. Exosomes are nano-sized microvesicle and contain various components such as nucleic acids, proteins, and lipids. Exosomes are important carriers for signal transmission or transportation of material from cell to cell or between cells and tissues. In recent years, exosomes have been considered as potential therapeutic targets of HCC. A large number of reports indicate that exosomes play a key role in the establishment of an HCC microenvironment, as well as the development, progression, invasion, met

SUBMITTER: Wang H 

PROVIDER: S-EPMC6902437 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature