Investigation of the host transcriptional response to intracellular bacterial infection using Dictyostelium discoideum as a host model.

ABSTRACT: BACKGROUND:During infection by intracellular pathogens, a highly complex interplay occurs between the infected cell trying to degrade the invader and the pathogen which actively manipulates the host cell to enable survival and proliferation. Many intracellular pathogens pose important threats to human health and major efforts have been undertaken to better understand the host-pathogen interactions that eventually determine the outcome of the infection. Over the last decades, the unicellular eukaryote Dictyostelium discoideum has become an established infection model, serving as a surrogate macrophage that can be infected with a wide range of intracellular pathogens. In this study, we use high-throughput RNA-sequencing to analyze the transcriptional response of D. discoideum when infected w

SUBMITTER: Kjellin J 

PROVIDER: S-EPMC6902447 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature