The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans.

ABSTRACT: BACKGROUND:Multicellular animals and bacteria frequently engage in predator-prey and host-pathogen interactions, such as the well-studied relationship between Pseudomonas aeruginosa and the nematode Caenorhabditis elegans. This study investigates the genomic and genetic basis of bacterial-driven variability in P. aeruginosa virulence towards C. elegans to provide evolutionary insights into host-pathogen relationships. RESULTS:Natural isolates of P. aeruginosa that exhibit diverse genomes display a broad range of virulence towards C. elegans. Using gene association and genetic analysis, we identify accessory genome elements that correlate with virulence, including both known and novel virulence determinants. Among the novel genes, we find a viral-like mobile element, the teg block, that imp

SUBMITTER: Vasquez-Rifo A 

PROVIDER: S-EPMC6902481 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature