IL-1β-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia.

ABSTRACT:

Background

Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer's disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance. We have previously shown that sustained expression of IL-1β in the hippocampus of APP/PS1 mice decreases amyloid plaque burden independent of recruited CCR2⁺ myeloid cells, suggesting resident microglia as the main phagocytic effectors of IL-1β-induced plaque clearance. To date, however, the mechanisms of IL-1β-induced plaque clearance remain poorly understood.

Methods

To determine whether microglia are involved in IL-1β-induced plaque clearance, APP/PS1 mice induced to express mature human IL-1β in the hippocampus via adenoviral transduction were treated w

SUBMITTER: Rivera-Escalera F 

PROVIDER: S-EPMC6902486 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature