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Association of age, sex and BMI with the rate of change in tibial cartilage volume: a 10.7-year longitudinal cohort study.

ABSTRACT: BACKGROUND:To describe the association of age, sex and body mass index with the rate of change of tibial knee cartilage volume over 10.7?years in a community-based sample of older adults. METHODS:Four hundred and eighty-one participants (49% female, mean age 60.8?years [range 51.1-79.7], 49% had knee pain and 58% radiographic osteoarthritis) were included. Tibial cartilage volume of the right knee was assessed on T1-weighted fat-suppressed 1.5?T MRI at baseline and 10.7?years. Data analyses were performed using linear regression models. RESULTS:The average rate of loss of cartilage volume was 1.2%/year (range 0.2-3.9%) with all participants losing cartilage volume over the study period. There was a significant association between age and loss of tibial cartilage volume in the medial (0.023%/year, 95% confidence interval [CI] 0.010 to 0.036%, p?

SUBMITTER: Cai G

PROVIDER: S-EPMC6902563 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Association of age, sex and BMI with the rate of change in tibial cartilage volume: a 10.7-year longitudinal cohort study.

Cai Guoqi G Jiang Matthew M Cicuttini Flavia F Jones Graeme G

Arthritis research & therapy 20191209 1

<h4>Background</h4>To describe the association of age, sex and body mass index with the rate of change of tibial knee cartilage volume over 10.7 years in a community-based sample of older adults.<h4>Methods</h4>Four hundred and eighty-one participants (49% female, mean age 60.8 years [range 51.1-79.7], 49% had knee pain and 58% radiographic osteoarthritis) were included. Tibial cartilage volume of the right knee was assessed on T1-weighted fat-suppressed 1.5 T MRI at baseline and 10.7 years. Dat ...[more]

PMID: 31818318

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Project description:PurposeHigh tibial osteotomy (HTO) is a surgical procedure used to correct abnormal mechanical loading of the knee joint; additionally, intra-articular hyaluronic acid injections have been shown to restore the viscoelastic properties of synovial fluid and balance abnormal biochemical processes. It was hypothesized that combining HTO with intra-articular hyaluronic acid injections would have benefit to improve the cartilage volume of knee joints.MethodsForty patients with medial compartment knee osteoarthritis (OA) were randomly placed into 1 of 2 groups. The study group (n = 20) received 2 cycles (at 6-month intervals) of 5 weekly intra-articular hyaluronic acid injections after HTO operation. The control group (n = 20) did not receive any intra-articular injections after HTO surgery. Cartilage volume (primary outcome) was assessed by magnetic resonance imaging (MRI) pre-operatively and 1 year post-operatively. Treatment efficacy (secondary outcomes) was evaluated with the Western Ontario and McMaster Universities OA Index (WOMAC) and by the comparison of the total rescue medication (paracetamol/diclofenac) used (weeks 6, 12, 24, 48).ResultsMRI studies showed a significant increase in total cartilage volume (p = 0.033), lateral femoral cartilage volume (p = 0.044) and lateral tibial cartilage volume (p = 0.027) in the study group. Cartilage volume loss was detected at the lateral tibial plateau in the control group. There were significant improvements after surgery in both groups for all subscales of WOMAC scores (p < 0.001) compared to the baseline. However, no difference was found between the two groups. The study group had significantly lower amounts of diclofenac consumption (p = 0.017).ConclusionBased on the findings of the present study, intra-articular hyaluronic acid injections may be beneficial for increasing total cartilage volume and preventing the loss of lateral tibiofemoral joint cartilage after HTO.Level of evidenceTherapeutic study, Level I.

Dataset Information

Association of age, sex and BMI with the rate of change in tibial cartilage volume: a 10.7-year longitudinal cohort study.

Publications

Association of age, sex and BMI with the rate of change in tibial cartilage volume: a 10.7-year longitudinal cohort study.

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