MiR-181b-5p May Regulate Muscle Growth in Tilapia by Targeting Myostatin b.

ABSTRACT: Background: Myostatin (Mstn), a member of the TGF-β superfamily, is a negative regulator of skeletal muscle mass in mammals. Precise regulation of Mstn expression is important for somite growth in fish. MicroRNA (miRNA), a type of small non-coding RNA, regulates gene expression at the post-transcriptional level and participates in various physiological functions. A growing amount of evidence has emphasized the importance of miRNA in the development of skeletal muscle. Aims: This study aims to study how miRNAs regulate myostatin b (mstnb) post-transcriptionally in tilapia. Methods/Results: Mstnb 3' UTR sequences were obtained, and the results of tissue distribution showed that mstnb was expressed in several tissues, including brain, white mus

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC6902659 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature