Coenzyme Q₁₀ alleviates tacrolimus-induced mitochondrial dysfunction in kidney.

ABSTRACT: The major side effect of tacrolimus (Tac) is nephrotoxicity. We studied whether supplementation of coenzyme Q₁₀, (CoQ₁₀) a potent antioxidant, can reduce Tac-induced nephrotoxicity via improving mitochondrial function. In an in vitro study, CoQ₁₀ reduced the production of Tac-induced mitochondrial reactive oxygen species and abolished the loss of mitochondrial membrane potential in proximal tubular cell line. Assessment of mitochondrial function revealed that CoQ₁₀ decreased oxygen consumption and mitochondrial respiration rate increased by Tac, suggesting improvement of mitochondrial function to synthesize ATP with CoQ₁₀ treatment. The effect of the CoQ₁₀ in vitro study was observed in an experimental m

SUBMITTER: Yu JH 

PROVIDER: S-EPMC6902707 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature