Susceptibility of microtubule-associated protein 1 light chain 3β (MAP1LC3B/LC3B) knockout mice to lung injury and fibrosis.

ABSTRACT: Insufficient autophagy has been reported in idiopathic pulmonary fibrosis (IPF) lungs. Specific roles of autophagy-related proteins in lung fibrosis development remain largely unknown. Here, we investigated the role of autophagy marker protein microtubule-associated protein 1 light chain 3β (LC3B) in the development of lung fibrosis. LC3B^-/- mice upon aging show smaller lamellar body profiles, increased cellularity, alveolar epithelial cell type II (AECII) apoptosis, surfactant alterations, and lysosomal and endoplasmic reticulum stress. Autophagosomal soluble N-ethylmaleimide-sensitive factor attachment protein receptor syntaxin 17 is increased in the AECII of aged LC3B^-/- mice and patients with IPF. Proteasomal activity, however, remained unaltered in

SUBMITTER: Kesireddy VS 

PROVIDER: S-EPMC6902724 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature