Association of Intestinal Alkaline Phosphatase With Necrotizing Enterocolitis Among Premature Infants.

ABSTRACT:

Importance

Necrotizing enterocolitis (NEC) in preterm infants is an often-fatal gastrointestinal tract emergency. A robust NEC biomarker that is not confounded by sepsis could improve bedside management, lead to lower morbidity and mortality, and permit patient selection in randomized clinical trials of possible therapeutic approaches.

Objective

To evaluate whether aberrant intestinal alkaline phosphatase (IAP) biochemistry in infant stool is a molecular biomarker for NEC and not associated with sepsis.

Design, setting, and participants

This multicenter diagnostic study enrolled 136 premature infants (gestational age, <37 weeks) in 2 hospitals in Louisiana and 1 hospital in Missouri. Data were collected and analyzed from May 2015 to November 2018.

Exposures

Inf

SUBMITTER: Heath M 

PROVIDER: S-EPMC6902776 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature