Assessment of the Association of D2 Dopamine Receptor Gene and Reported Allele Frequencies With Alcohol Use Disorders: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The association between the D2 dopamine receptor gene (DRD2) Taq1A locus (rs1800497) and alcohol use disorder (AUD) is enduring but the subject of long-standing controversy; meta-analysis of studies across 3 decades shows an association between rs1800497 and AUD, but genome-wide analyses have detected no role for rs1800497 in any phenotype. No evidence has emerged that rs1800497, which is located in ANKK1, perturbs the expression or function of DRD2.

Objective

To resolve contradictions in previous studies by identifying hidden confounders and assaying for functional effects of rs1800497 and other loci in the DRD2 region.

Data sources

PubMed (882 studies), Embase (1056 studies), and Web of Science (501 studies) databases were searched through August 2018. Th

SUBMITTER: Jung Y 

PROVIDER: S-EPMC6902783 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature