Research Techniques Made Simple: Murine Models of Human Psoriasis.

ABSTRACT: Psoriasis vulgaris is a common, inflammatory skin disease affecting approximately 3% of the population in the United States. The etiology of psoriasis and its associated comorbidities are complex and the result of complicated interactions between the skin, immune system, disease-associated susceptibility loci, and multiple environmental triggers. The modeling of human disease in vivo through the use of murine models represents a powerful, indispensable tool for investigating the immune and genetic mechanisms contributing to a clinical disease phenotype. Nevertheless, modeling a complex, multigenic disease like psoriasis in mice has proven to be extremely challenging and is associated with significant limitations. Over the last four decades, more than 40 unique mouse models for psoriasis ha

SUBMITTER: Hawkes JE 

PROVIDER: S-EPMC6902858 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature