The gut microbiome-joint connection: implications in osteoarthritis.

ABSTRACT:

Purpose of review

Osteoarthritis is a debilitating disease leading to joint degeneration, inflammation, pain, and disability. Despite efforts to develop a disease modifying treatment, the only accepted and available clinical approaches involve palliation. Although many factors contribute to the development of osteoarthritis, the gut microbiome has recently emerged as an important pathogenic factor in osteoarthritis initiation and progression. This review examines the literature to date regarding the link between the gut microbiome and osteoarthritis.

Recent findings

Studies showing correlations between serum levels of bacterial metabolites and joint degeneration were the first links connecting a dysbiosis of the gut microbiome with osteoarthritis. Further investigations have

SUBMITTER: Favazzo LJ 

PROVIDER: S-EPMC6903327 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature