Differentially methylated gene patterns between age-matched sarcopenic and non-sarcopenic women.

ABSTRACT:

Background

Sarcopenia is characterized by progressive decreases in muscle mass, muscle strength, and muscle function with ageing. Although many studies have investigated the mechanisms of sarcopenia, its connection with epigenetic factors, such as DNA methylation, still remains poorly understood. The aim of this study was to explore sarcopenia-related DNA methylation differences in blood samples between age-matched sarcopenic and non-sarcopenic older women.

Methods

A sarcopenic group (n = 24) was identified and selected from a set of 247 older Caucasian women (aged 65-80 years) based on cut-off points of skeletal muscle index at 6.75 kg/m² and grip strength at 26 kg (the lower quintile of grip strength in the set). A non-sarcopenic group (n = 24) was created with

SUBMITTER: He L 

PROVIDER: S-EPMC6903450 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature