Short-Term Stability of Hematologic Parameters in Frozen Whole Blood.

ABSTRACT:

Background

Complete blood counts (CBCs) are commonly obtained in large multicenter studies. We assessed the stability of 10 parameters after short-term (up to 30 days) frozen storage.

Methods

We compared CBC measurements from fresh samples (n = 53) with samples stored for up to 30 days at -70 °C. We calculated the CVs and intraclass correlation coefficients.

Results

Mean values of most parameters, with the exception of hemoglobin and platelet count, were significantly different by 15 days of storage. White blood cell count (CV, 38.3%; 95% CI, 31.3%-46.2%) and red cell distribution width (CV, 37.7%; 95% CI, 34.1%-41.3%) were the most variable. After 30 days, only hemoglobin remained stable and reliable (CV, 0.8%; 95% CI, 0.4%-1.3%).

Conclusions

Hemoglobin remain

SUBMITTER: Tang O 

PROVIDER: S-EPMC6903686 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature