RBM3 and CIRP expressions in targeted temperature management treated cardiac arrest patients-A prospective single center study.

ABSTRACT: BACKGROUND:Management of cardiac arrest patients includes active body temperature control and strict prevention of fever to avoid further neurological damage. Cold-shock proteins RNA-binding motif 3 (RBM3) and cold inducible RNA-binding protein (CIRP) expressions are induced in vitro in response to hypothermia and play a key role in hypothermia-induced neuroprotection. OBJECTIVE:To measure gene expressions of RBM3, CIRP, and inflammatory biomarkers in whole blood samples from targeted temperature management (TTM)-treated post-cardiac arrest patients for the potential application as clinical biomarkers for the efficacy of TTM treatment. METHODS:A prospective single center trial with the inclusion of 22 cardiac arrest patients who were treated with TTM (33°C for 24 hours) after ROSC was perf

SUBMITTER: Rosenthal LM 

PROVIDER: S-EPMC6903712 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature