Persistence of Burkholderia thailandensis E264 in lung tissue after a single binge alcohol episode.

ABSTRACT: BACKGROUND:Binge drinking, an increasingly common form of alcohol use disorder, is associated with substantial morbidity and mortality; yet, its effects on the immune system's ability to defend against infectious agents are poorly understood. Burkholderia pseudomallei, the causative agent of melioidosis can occur in healthy humans, yet binge alcohol intoxication is increasingly being recognized as a major risk factor. Although our previous studies demonstrated that binge alcohol exposure increased B. pseudomallei near-neighbor virulence in vivo and increased paracellular diffusion and intracellular invasion, no experimental studies have examined the extent to which bacterial and alcohol dosage play a role in disease progression. In addition, the temporal effects of a single binge alcohol d

SUBMITTER: Jimenez VM 

PROVIDER: S-EPMC6903738 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature