Comparative analysis of small RNAs released by the filarial nematode Litomosoides sigmodontis in vitro and in vivo.

ABSTRACT:

Background

The release of small non-coding RNAs (sRNAs) has been reported in parasitic nematodes, trematodes and cestodes of medical and veterinary importance. However, little is known regarding the diversity and composition of sRNAs released by different lifecycle stages and the portion of sRNAs that persist in host tissues during filarial infection. This information is relevant to understanding potential roles of sRNAs in parasite-to-host communication, as well as to inform on the location within the host and time point at which they can be detected.

Methodology and principal findings

We have used small RNA (sRNA) sequencing analysis to identify sRNAs in replicate samples of the excretory-secretory (ES) products of developmental stages of the filarial nematode Litomosoides

SUBMITTER: Quintana JF 

PROVIDER: S-EPMC6903752 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature