Dynamical comparison between Drosha and Dicer reveals functional motion similarities and dissimilarities.

ABSTRACT: Drosha and Dicer are RNase III family members of classes II and III, respectively, which play a major role in the maturation of micro-RNAs. The two proteins share similar domain arrangement and overall fold despite no apparent sequence homology. The overall structural and catalytic reaction similarity of both proteins, on the one hand, and differences in the substrate and its binding mechanisms, on the other, suggest that both proteins also share dynamic similarities and dissimilarities. Since dynamics is essential for protein function, a comparison at their dynamics level is fundamental for a complete understanding of the overall relations between these proteins. In this study, we present a dynamical comparison between human Drosha and Giardia Dicer. Gaussian Network Model and Anisotropic

SUBMITTER: Aharoni R 

PROVIDER: S-EPMC6903759 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature