Programming of Distinct Chemokine-Dependent and -Independent Search Strategies for Th1 and Th2 Cells Optimizes Function at Inflamed Sites.

ABSTRACT: T-helper (Th) cell differentiation drives specialized gene programs that dictate effector T cell function at sites of infection. Here, we have shown Th cell differentiation also imposes discrete motility gene programs that shape Th1 and Th2 cell navigation of the inflamed dermis. Th1 cells scanned a smaller tissue area in a G protein-coupled receptor (GPCR) and chemokine-dependent fashion, while Th2 cells scanned a larger tissue area independent of GPCR signals. Differential chemokine reliance for interstitial migration was linked to STAT6 transcription-factor-dependent programming of integrin α_Vβ₃ expression: Th2 cell differentiation led to high α_Vβ₃ expression relative to Th1 cells. Th1 and Th2 cell modes of motility could be switched simply by

SUBMITTER: Gaylo-Moynihan A 

PROVIDER: S-EPMC6904228 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature