Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis.

ABSTRACT:

Background

Mendelian randomization studies in adults suggest that abdominal adiposity is causally associated with increased risk of type 2 diabetes and coronary artery disease in adults, but its causal effect on cardiometabolic risk in children remains unclear.

Objective

We aimed to study the causal relation of abdominal adiposity with cardiometabolic risk factors in children by applying Mendelian randomization.

Methods

We constructed a genetic risk score (GRS) using variants previously associated with waist-to-hip ratio adjusted for BMI (WHRadjBMI) and examined its associations with cardiometabolic factors by linear regression and Mendelian randomization in a meta-analysis of 6 cohorts, including 9895 European children and adolescents aged 3-17 y.

Results

WHRa

SUBMITTER: Viitasalo A 

PROVIDER: S-EPMC6904295 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature