Dopamine depletion alters macroscopic network dynamics in Parkinson's disease.

ABSTRACT: Parkinson's disease is primarily characterized by diminished dopaminergic function; however, the impact of these impairments on large-scale brain dynamics remains unclear. It has been difficult to disentangle the direct effects of Parkinson's disease from compensatory changes that reconfigure the functional signature of the whole brain network. To examine the causal role of dopamine depletion in network-level topology, we investigated time-varying network structure in 37 individuals with idiopathic Parkinson's disease, both ON and OFF dopamine replacement therapy, along with 50 age-matched, healthy control subjects using resting state functional MRI. By tracking dynamic network-level topology, we found that the Parkinson's disease OFF state was associated with greater network-level integra

SUBMITTER: Shine JM 

PROVIDER: S-EPMC6904322 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature