Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids.

ABSTRACT: The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown. Here, we show that cochlear rhythms are system driven and require local Bmal1 as well as central input from the suprachiasmatic nuclei (SCN). SCN ablations disrupted the circadian expression of the core clock genes in the cochlea. Because the circadian secretion of glucocorticoids (GCs) is controlled by the SCN and GCs are known to modulate auditory function, we assessed their influence on circadian gene expression. Removal of circulating GCs by adrenalectomy (ADX) did not have a major impact on core clock gene expression in the cochlea. Rather it abolished the transcription of clock-controlled genes involved in inflammatio

SUBMITTER: Cederroth CR 

PROVIDER: S-EPMC6904421 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature