Coordinating septum formation and the actomyosin ring during cytokinesis in Schizosaccharomyces pombe.

ABSTRACT: During cytokinesis, animal and fungal cells form a membrane furrow via actomyosin ring constriction. Our understanding of actomyosin ring-driven cytokinesis stems extensively from the fission yeast model system. However, unlike animal cells, actomyosin ring constriction occurs simultaneously with septum formation in fungi. While the formation of an actomyosin ring is essential for cytokinesis in fission yeast, proper furrow formation also requires septum deposition. The molecular mechanisms of spatiotemporal coordination of septum deposition with actomyosin ring constriction are poorly understood. Although the role of the actomyosin ring as a mechanical structure driving furrow formation is better understood, its role as a spatiotemporal landmark for septum deposition is not widely discuss

SUBMITTER: Hercyk BS 

PROVIDER: S-EPMC6904431 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature