Chronic corticosterone administration induces negative valence and impairs positive valence behaviors in mice.

ABSTRACT: Behavioral approaches utilizing rodents to study mood disorders have focused primarily on negative valence behaviors associated with potential threat (anxiety-related behaviors). However, for disorders such as depression, positive valence behaviors that assess reward processing may be more translationally valid and predictive of antidepressant treatment outcome. Chronic corticosterone (CORT) administration is a well-validated pharmacological stressor that increases avoidance in negative valence behaviors associated with anxiety^1-4. However, whether chronic stress paradigms such as CORT administration also lead to deficits in positive valence behaviors remains unclear. We treated male C57BL/6J mice with chronic CORT and assessed both negative and positive valence behaviors. We fo

SUBMITTER: Dieterich A 

PROVIDER: S-EPMC6904464 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature