Plasma Transthyretin as a Predictor of Amnestic Mild Cognitive Impairment Conversion to Dementia.

ABSTRACT: Amnestic mild cognitive impairment (MCI) is a prodromal stage of dementia, with a higher incidence of these patients progressing to Alzheimer's disease (AD) than normal aging people. A biomarker for the early detection and prediction for this progression is important. We recruited MCI subjects in three teaching hospitals and conducted longitudinal follow-up for 5 years at one-year intervals. Cognitively healthy controls were recruited for comparisom at baseline. Plasma transthyretin (TTR) levels were measured by ELISA. Survival analysis with time to AD conversion as an outcome variable was calculated with the multivariable Cox proportional hazards models using TTR as a continuous variable with adjustment for other covariates and bootstrapping resampling analysis. In total, 184 MCI subjects

SUBMITTER: Tien YT 

PROVIDER: S-EPMC6904474 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature