Sec62 promotes early recurrence of hepatocellular carcinoma through activating integrinα/CAV1 signalling.

ABSTRACT: Postsurgical recurrence within 2 years is the major cause of poor survival of hepatocellular carcinoma (HCC) patients. However, the molecular mechanism underlying HCC recurrence remains unclear. Here, we distinguish the function and mechanism of Sec62 in promoting HCC recurrence. The correlation between Sec62 and early recurrence was demonstrated in 60 HCC samples from a prospective study. HCC cells with Sec62 knockdown (Sec62^KD) or overexpression (Sec62^OE) were used to determine the potential of Sec62 in cell migration in vitro. Microarray analysis comparing Sec62^KD or Sec62^OE to their control counterparts was used to explore the mechanisms of Sec62-induced recurrence. A luciferase-labelled orthotopic nude mouse model of HCC with Sec62^KD

SUBMITTER: Du J 

PROVIDER: S-EPMC6904485 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature