Bayesian clinical trials at The University of Texas MD Anderson Cancer Center: An update.

ABSTRACT:

Background/aims

In our 2009 article, we showed that Bayesian methods had established a foothold in developing therapies in our institutional oncology trials. In this article, we will document what has happened since that time. In addition, we will describe barriers to implementing Bayesian clinical trials, as well as our experience overcoming them.

Methods

We reviewed MD Anderson Cancer Center clinical trials submitted to the institutional protocol office for scientific and ethical review between January 2009 and December 2013, the same length time period as the previous article. We tabulated Bayesian methods implemented for design or analyses for each trial and then compared these to our previous findings.

Results

Overall, we identified 1020 trials and found that 283

SUBMITTER: Tidwell RSS 

PROVIDER: S-EPMC6904523 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature