Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn's disease.

ABSTRACT: Leptin has been shown to modulate intestinal inflammation in mice. However, clinical evidence regarding its immune-stimulatory potential in human Crohn's disease remains sparse. We here describe a patient with the unique combination of acquired generalized lipodystrophy and Crohn's disease (AGLCD) featuring a lack of adipose tissue, leptin deficiency and intestinal inflammation. Using mass and flow cytometry, immunohistochemistry and functional metabolic analyses, the AGLCD patient was compared to healthy individuals and Crohn's disease patients regarding immune cell composition, function and metabolism and the effects of recombinant N-methionylleptin (rLeptin) were evaluated. We provide evidence that rLeptin exerts diverse pro-inflammatory effects on immune cell differentiation and functi

SUBMITTER: Ziegler JF 

PROVIDER: S-EPMC6904732 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature