Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma.

ABSTRACT:

Background

Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to use whole genome sequencing (WGS) data to identify regions of common genetic variation contributing to lung function in individuals with a diagnosis of asthma.

Methods

WGS data were generated for 1,053 individuals from trios and extended pedigrees participating in the family-based Genetic Epidemiology of Asthma in Costa Rica study. Asthma affection status was defined through a physician's diagnosis of asthma, and most participants with asthma also had airway hyperresponsiveness (AHR) to methacholine. Family-based association tests for single variants were performed to assess the associations with lung function phenotypes.

Results

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SUBMITTER: Kachroo P 

PROVIDER: S-EPMC6904857 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature