Induced pluripotent stem cells for therapy personalization in pediatric patients: Focus on drug-induced adverse events.

ABSTRACT: Adverse drug reactions (ADRs) are major clinical problems, particularly in special populations such as pediatric patients. Indeed, ADRs may be caused by a plethora of different drugs leading, in some cases, to hospitalization, disability or even death. In addition, pediatric patients may respond differently to drugs with respect to adults and may be prone to developing different kinds of ADRs, leading, in some cases, to more severe consequences. To improve the comprehension, and thus the prevention, of ADRs, the set-up of sensitive and personalized assays is urgently needed. Important progress is represented by the possibility of setting up groundbreaking patient-specific assays. This goal has been powerfully achieved using induced pluripotent stem cells (iPSCs). Due to their genetic and p

SUBMITTER: Genova E 

PROVIDER: S-EPMC6904863 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature