Factors influencing adherence in a trial of early introduction of allergenic food.

ABSTRACT:

Background

The Enquiring About Tolerance (EAT) study examined whether the early introduction of 6 allergenic foods from 3 months of age in exclusively breastfed infants prevented the development of food allergy. The intervention was effective in the per-protocol analysis for allergy to 1 or more foods and for egg and peanut individually, but only 42% of early introduction group (EIG) children met the per-protocol criteria.

Objective

We sought to identify which factors were responsible for nonadherence in the EAT study.

Methods

Factors influencing adherence within the key early introduction period in the EIG (up to 6 months of age) were divided into enrollment and postenrollment factors, and their association with nonadherence was explored.

Results

In an adjuste

SUBMITTER: Perkin MR 

PROVIDER: S-EPMC6904906 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature