Clinical and Genetic Predictors of Priapism in Sickle Cell Disease: Results from the Recipient Epidemiology and Donor Evaluation Study III Brazil Cohort Study.

ABSTRACT: Introduction:Priapism is the persistent and painful erection of the penis and is a common sickle cell disease (SCD) complication.

Aim:The goal of this study was to characterize clinical and genetic factors associated with priapism within a large multi-center SCD cohort in Brazil.

Methods:Cases with priapism were compared to SCD type-matched controls within defined age strata to identify clinical outcomes associated with priapism. Whole blood single nucleotide polymorphism genotyping was performed using a customized array, and a genome-wide association study (GWAS) was conducted to identify single nucleotide polymorphisms associated with priapism.

Main outcome measure:Of the 1,314 male patients in the cohort, 188 experienced priapism (14.3%).

SUBMITTER: Cintho Ozahata M 

PROVIDER: S-EPMC6904926 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature