Patterns of Immune Infiltration in HNC and Their Clinical Implications: A Gene Expression-Based Study.

ABSTRACT: Background: Immune infiltration of head and neck cancer (HNC) highly correlated with the patient's prognosis. However, previous studies failed to explain the diversity of different cell types that make up the function of the immune response system. The aim of the study was to uncover the differences in immune phenotypes of the tumor microenvironment (TME) between HNC adjacent tumor tissues and tumor tissues using CIBERSORT method and explore their therapeutic implications. Method: In current work, we employed the CIBERSORT method to evaluate the relative proportions of immune cell profiling in 11 paired HNC and adjacent samples, and analyzed the correlation between immune cell infiltration and clinical information. The tumor-infiltrating immune cells of TCGA HNC cohort was an

SUBMITTER: Song J 

PROVIDER: S-EPMC6904960 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature