Serum levels of the chemokine CCL2 are elevated in malignant pleural mesothelioma patients.

ABSTRACT:

Background

Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammatory response. Repeated exposure to asbestos fibers results in a prolonged inflammatory response and cycles of tissue damage and repair. The inflammation-associated cycles of tissue damage and repair are intimately involved in the development of asbestos-associated cancers. Macrophages are a key component of asbestos-associated inflammation and play essential roles in the etiology of a variety of cancers. Macrophages are also a source of C-C motif chemokine ligand 2 (CCL2), and a variety of tumor-types express CCL2. High levels of CCL2 are present in the pleural effus

SUBMITTER: Kishimoto T 

PROVIDER: S-EPMC6905076 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature